abstract：:Serotonin (5HT) is a powerful modulator of respiratory circuitry in vitro but its role in the development of breathing behavior in vivo is poorly understood. Here we show, using 5HT neuron-deficient Pet-1 (Pet-1(-/-)) neonates, that serotonergic function is required for the normal timing of postnatal respiratory matur...

journal_title：Respiratory physiology & neurobiology

authors： Erickson JT,Shafer G,Rossetti MD,Wilson CG,Deneris ES

更新日期：2007-10-15 00:00:00

abstract：UNLABELLED:In seven patients with idiopathic or secondary pulmonary arterial hypertension (PAH), ventilation-perfusion (V (A)/Q ) relationships were measured during a right heart catheterization using the multiple inert-gas elimination technique before and during intravenous infusion with epoprostenol (EPO), and follow...

journal_title：Respiratory physiology & neurobiology

authors： Bratel T,Lagerstrand L,Brodin LA,Nowak J,Randmaa I

更新日期：2007-08-15 00:00:00

abstract：:We studied the influence of hypercapnic acidosis and hypoxia on the neural drive to abdominal muscles in anesthetized and decerebrate rats; this information is unavailable despite widespread use of the rat as an experimental model in respiratory physiology and neurobiology. To minimize confounding influences from rece...

journal_title：Respiratory physiology & neurobiology

authors： Iizuka M,Fregosi RF

更新日期：2007-08-01 00:00:00

abstract：:Changes in pulmonary hemodynamics modify the mechanical properties of the lungs. The effects of alterations in pulmonary capillary pressure (Pc) were investigated on the airway and lung tissue mechanics during positive-pressure ventilation and following lung recruitment maneuvers. Isolated, mechanically normoventilate...

journal_title：Respiratory physiology & neurobiology

authors： Albu G,Habre W,Fontao F,Morel DR,Petak F

更新日期：2007-08-01 00:00:00

abstract：:We assessed upper airway responses to acute and chronic inspiratory loading. In Experiment I, 11 healthy subjects underwent T(2)-weighted magnetic resonance imaging (MRI) of upper airway dilator muscles (genioglossus and geniohyoid) before and up to 10 min after a single bout of pressure threshold inspiratory muscle t...

journal_title：Respiratory physiology & neurobiology

authors： How SC,McConnell AK,Taylor BJ,Romer LM

更新日期：2007-08-01 00:00:00

abstract：:Slices of rat carotid bodies, or cultured glomus cells, were used to study intercellular coupling. This phenomenon occurs because gap junctions allow passage of currents and dyes from one cell to another. There is a two-way resistive coupling between glomus cells (GC/GC coupling), which is accompanied by activity of i...

journal_title：Respiratory physiology & neurobiology

authors： Eyzaguirre C

更新日期：2007-07-01 00:00:00

abstract：:AMP-activated protein kinase (AMPK) is a key component of a kinase cascade that regulates energy balance at the cellular level. Our recent research has raised the possibility that AMPK may also function to couple hypoxic inhibition of mitochondrial oxidative phosphorylation to O(2)-sensitive K(+) channel inhibition an...

journal_title：Respiratory physiology & neurobiology

authors： Wyatt CN,Evans AM

更新日期：2007-07-01 00:00:00

abstract：:We used quantitative single photon emission computed tomography to estimate the proportion of the observed redistribution of blood flow and ventilation that is due to lung tissue shift with a change in posture. Seven healthy volunteers were studied awake, breathing spontaneously. Regional blood flow and ventilation we...

journal_title：Respiratory physiology & neurobiology

authors： Petersson J,Rohdin M,Sánchez-Crespo A,Nyrén S,Jacobsson H,Larsson SA,Lindahl SG,Linnarsson D,Neradilek B,Polissar NL,Glenny RW,Mure M

更新日期：2007-06-15 00:00:00

abstract：:Human ventilation is aperiodic, exhibiting a breath-by-breath variability and a complexity of which the characteristics may be interesting physiologically and clinically. In the present study, we tested the ability of respiratory inductive plethysmography (RIP) to describe these properties. Indeed, RIP does not have t...

journal_title：Respiratory physiology & neurobiology

authors： Fiamma MN,Samara Z,Baconnier P,Similowski T,Straus C

更新日期：2007-05-14 00:00:00

abstract：:The present studies evaluate whether the vagus nerves link the lungs' immune and neural systems by transmitting information through pulmonary nociceptors. Single unit activities from pulmonary nociceptors [C fiber receptors (CFRs) and high threshold Adelta fiber receptors (HTARs)] were recorded from the cervical vagus...

journal_title：Respiratory physiology & neurobiology

authors： Yu J,Lin S,Zhang J,Otmishi P,Guardiola JJ

更新日期：2007-05-14 00:00:00

abstract：:We have observed that pulmonary rapidly adapting receptor activity is greater in emphysematous rats than in controls. Pulmonary receptor activity, if modified by lung disease, may produce an inappropriate drive to breathe which may be perceived as dyspnoea. To investigate the efferent (drive) component of this hypothe...

journal_title：Respiratory physiology & neurobiology

authors： Dallak MA,Pirie LJ,Davies A

更新日期：2007-04-16 00:00:00

abstract：:We hypothesized that progesterone may enhance the hypoxic ventilatory response and reduce the occurrence of apneas in newborn male rats. We studied 10-day-old rats chronically exposed to progesterone (Prog) or vehicle through the milk of lactating mothers. Respiratory and metabolic recordings were performed using whol...

journal_title：Respiratory physiology & neurobiology

authors： Lefter R,Morency CE,Joseph V

更新日期：2007-04-16 00:00:00

abstract：:The physiologic function of nasal nitric oxide (NO) release is unknown. In prior experiments, topical NG-nitro-L-arginine methyl ester (L-NAME) on nasal mucosa reduced exhaled nasal NO output and caused daytime sleepiness. We hypothesized that nasal NO output is reduced at night during the sleep period. We measured ex...

journal_title：Respiratory physiology & neurobiology

authors： O'Hearn DJ,Giraud GD,Sippel JM,Edwards C,Chan B,Holden WE

更新日期：2007-04-16 00:00:00

abstract：:Genetic deficiency of the muscle chloride channel CLC-1 leads to myotonia congenita in humans as well as myotonia in mice and goats. The hallmark of myotonia is delayed muscle relaxation due to persistent electrical discharges in the muscle. The present study tested the hypothesis that performance of CLC-1 deficient d...

journal_title：Respiratory physiology & neurobiology

authors： van Lunteren E,Moyer M,Pollarine J

更新日期：2007-03-15 00:00:00

abstract：:It had been demonstrated previously that the circadian patterns of activity and state of arousal are not essential for the manifestation of the daily patterns of pulmonary ventilation (V(E)), tidal volume (V(T)) and breathing frequency (f). In this study we investigated the extent of the linkage between the circadian ...

journal_title：Respiratory physiology & neurobiology

authors： Mortola JP

更新日期：2007-02-15 00:00:00

abstract：:Airway injury in infant monkeys exposed to ozone and/or house dust mite allergen (HDMA) is associated with a loss of epithelial innervation. In this study, we evaluated for persistence/recovery of the altered epithelial innervation. Thirty-day-old rhesus monkeys were exposed to repeated episodes of HDMA and/or ozone f...

journal_title：Respiratory physiology & neurobiology

authors： Kajekar R,Pieczarka EM,Smiley-Jewell SM,Schelegle ES,Fanucchi MV,Plopper CG

更新日期：2007-01-15 00:00:00

abstract：:This study tested the hypothesis that apnoea index would be greater during daytime sleep than nighttime sleep in the rat. Electroencephalogram and electromyogram were monitored via biotelemetry implant and respiration was measured using whole body plethysmography in six male rats in two separate 34h recording sessions...

journal_title：Respiratory physiology & neurobiology

authors： Stephenson R,Horner RL

更新日期：2006-12-01 00:00:00

abstract：:In aquatic vertebrates, peripheral O(2) chemoreceptors initiate compensatory physiological and behavioural responses to hypoxia, beginning at very early stages of development, to maintain sufficient gas exchange across the skin or gills. This review highlights the morphological and physiological studies, particularly ...

journal_title：Respiratory physiology & neurobiology

authors： Jonz MG,Nurse CA

更新日期：2006-11-01 00:00:00

abstract：:While a large surface area combined with short diffusion distances make fish gills well suited for gas exchange, these properties leads to costly water and ion fluxes and exposure to toxic substances and pathogens. Thus, gill morphology is likely to be a compromise between opposing demands. It has become clear that so...

journal_title：Respiratory physiology & neurobiology

authors： Sollid J,Nilsson GE

更新日期：2006-11-01 00:00:00

abstract：:The mechanisms involved in the pathogenesis of pulmonary arterial hypertension (PAH) remain unclear. Nitric oxide (NO) centrally attenuates sympathetic outflow and, therefore, may chronically modulate pulmonary arterial pressure (PAP), especially during the development of chronic hypoxia-induced PAH. To test this hypo...

journal_title：Respiratory physiology & neurobiology

authors： Schwenke DO,Pearson JT,Mori H,Shirai M

更新日期：2006-10-27 00:00:00

abstract：:We examined how the greater vasodilatory capacity of slow--(ST) versus fast-twitch (FT) muscles impacts the relationship between blood flow (Q ) and O2 uptake (VO2) and, consequently, the O2 extraction (a-vO2 diff.)-to-VO2 relationship. Q was measured with radiolabelled microspheres, while VO2 was calculated by the Fi...

journal_title：Respiratory physiology & neurobiology

authors： Ferreira LF,McDonough P,Behnke BJ,Musch TI,Poole DC

更新日期：2006-10-27 00:00:00

abstract：:The mass spectrometer (MS) traditionally has been the instrument of choice for measuring cardiac output (Q (T)) non-invasively using the foreign gas uptake method. However, the size and cost of the MS has hampered widespread adoption of this technique outside of the laboratory. Here, we present results, from six norma...

journal_title：Respiratory physiology & neurobiology

authors： Baum MM,Moss JA,Kumar S,Wagner PD

更新日期：2006-09-28 00:00:00

abstract：:The pathophysiology of systemic lupus erythematosus (SLE) has been very well described in many organs. However, the relation between extracellular matrix changes and lung dynamic mechanical behaviour deserves elucidation. To that end, pulmonary mechanics, lung morphometry and the amount of collagen and elastic fibres ...

journal_title：Respiratory physiology & neurobiology

authors： Souza-Fernandes AB,Rocco PR,Contador RS,Menezes SL,Faffe DS,Negri EM,Capelozzi VL,Zin WA

更新日期：2006-08-01 00:00:00

abstract：:We questioned the assumption that polycythemia is essential for adaptation to chronic hypoxia. Thus, the objective of our study was to determine if anemic Epo-TAg(h) mice could survive in hypoxia despite low oxygen carrying capacity. We explored the possibility that ventilatory acclimatisation is involved in the strat...

journal_title：Respiratory physiology & neurobiology

authors： Macarlupú JL,Buvry A,Morel OE,León-Velarde F,Richalet JP,Favret F

更新日期：2006-08-01 00:00:00

abstract：:The cough reflex pathway is characterized by a remarkable plasticity often resulting in a persistent and uncontrollable urge to cough during airway inflammation. In many instances cough becomes up regulated to the extent that ceases to fulfill its defensive role in protecting the airways. The exact mechanisms underlyi...

journal_title：Respiratory physiology & neurobiology

authors： Carr MJ,Lee LY

更新日期：2006-07-28 00:00:00

abstract：:To evaluate whether respiratory factors limit exercise capacity in patients with mild cystic fibrosis (CF) lung disease (mean FEV(1) = 76 +/- 7.7% predicted) we stressed the respiratory system of seven patients using added dead space (V(D)). Primary outcomes were exercise duration (Ex(dur)) and maximal oxygen uptake (...

journal_title：Respiratory physiology & neurobiology

authors： Dodd JD,Barry SC,Gallagher CG

更新日期：2006-06-01 00:00:00

abstract：:It is well established that women exhibit several anatomic and physiologic characteristics that distinguish their responses to exercise from those of men. These factors have been shown to influence the training response and contribute to lower maximal aerobic power in women. Additionally, the reproductive hormones, es...

journal_title：Respiratory physiology & neurobiology

authors： Harms CA

更新日期：2006-04-28 00:00:00

abstract：:This review summarizes the recent neuroanatomical and physiological studies that form the neural basis for the state-dependent changes in airway resistance. Here, we review only the interactions between the brain regions generating quiet (non-rapid eye movement, NREM) and active (rapid eye movement, REM) sleep stages ...

journal_title：Respiratory physiology & neurobiology

authors： Haxhiu MA,Rust CF,Brooks C,Kc P

更新日期：2006-03-28 00:00:00

abstract：:Ventilation (V (A)) to perfusion (Q ) heterogeneity (V (A)/Q ) analyses by a two-compartment lung model (2C), utilizing routine gas exchange measurements and a computer solution to account for O(2) and CO(2) measurements, were compared with multiple inert gas elimination technique (MIGET) analyses and a multi-compartm...

journal_title：Respiratory physiology & neurobiology

authors： Loeppky JA,Caprihan A,Altobelli SA,Icenogle MV,Scotto P,Vidal Melo MF

更新日期：2006-03-28 00:00:00

abstract：:Preoperative prediction of a successful outcome following lung volume reduction surgery (LVRS) for emphysema is imperfect. One mechanism could be improvement in respiratory muscle function yet controversy exists regarding the magnitude and mechanism of such an improvement. Therefore, we measured diaphragm strength in ...

journal_title：Respiratory physiology & neurobiology

authors： Hamnegård CH,Polkey MI,Thylen A,Nilsson F,Schersten H,Bake B

更新日期：2006-02-28 00:00:00

abstract：:Our primary hypothesis was that the acute ventilatory response to carbon dioxide in the presence of sustained hypoxia {VRCO2 (hypoxia)} or hyperoxia {VRCO2 (hyperoxia)} would increase in subjects with obstructive sleep apnea (OSA) after exposure to episodic hypoxia. Secondarily, we hypothesized that chronic (i.e. year...

journal_title：Respiratory physiology & neurobiology

authors： Khodadadeh B,Badr MS,Mateika JH

更新日期：2006-02-28 00:00:00

abstract：:Breathing movements require the coordinated recruitment of cranial and spinal motoneurons innervating muscles of the upper airway and ribcage. A significant part of respiratory motoneuron development and maturation occurs prenatally to support the generation of fetal breathing movements in utero and sustained breathin...

journal_title：Respiratory physiology & neurobiology

authors： Greer JJ,Funk GD

更新日期：2005-11-15 00:00:00

abstract：:Exposure to tobacco smoke is a major risk factor for the sudden infant death syndrome. Nicotine is thought to be the ingredient in tobacco smoke that is responsible for a multitude of cardiorespiratory effects during development, and pre- rather than postnatal exposure is considered to be most detrimental. Nicotine in...

journal_title：Respiratory physiology & neurobiology

authors： Hafström O,Milerad J,Sandberg KL,Sundell HW

更新日期：2005-11-15 00:00:00

abstract：:Recent in vitro data suggest that astrocytes may modulate respiration. To examine this question in vivo, we treated 5-day-old rat pups with methionine sulfoximine (MS), a compound that alters carbohydrate and glutamate metabolism in astrocytes, but not neurons. MS-treated pups displayed a reduced breathing frequency (...

journal_title：Respiratory physiology & neurobiology

authors： Young JK,Dreshaj IA,Wilson CG,Martin RJ,Zaidi SI,Haxhiu MA

更新日期：2005-05-12 00:00:00

abstract：:The intrinsic positive-end-expiratory pressure (PEEPi) increases the inspiratory load, the cost of breathing and thus oxygen consumption (V(O2)). It has been shown that applying an extrinsic positive-end-expiratory pressure (PEEPe) reduces the inspiratory threshold load but the optimal PEEPe level is still in debate. ...

journal_title：Respiratory physiology & neurobiology

authors： Glérant JC,Leleu O,Rose D,Mayeux I,Jounieaux V

更新日期：2005-04-15 00:00:00

abstract：:We studied the effect of N(w)-nitro-L-arginine (NLA) on yak pulmonary vascular tone in a climatic (hypobaric/hyperbaric adjusted) chamber. Five young male yaks that had been born and reared at an altitude greater than 3800 m a.s.l. were used. After measuring control values, 20 mg/kg of NLA was administered via the jug...

journal_title：Respiratory physiology & neurobiology

authors： Ishizaki T,Koizumi T,Ruan Z,Wang Z,Chen Q,Sakai A

更新日期：2005-04-15 00:00:00

abstract：:Increased transdiaphragmatic pressure, reduced muscle blood flow, and increased duty cycle have all been associated with a reduction in the center frequency (CFdi) of the diaphragm's electrical activity (EAdi). However, the specific influence of diaphragm activation on CFdi is unknown. We evaluated whether increased d...

journal_title：Respiratory physiology & neurobiology

authors： Spahija J,Beck J,Lindström L,Bégin P,de Marchie M,Sinderby C

更新日期：2005-03-01 00:00:00

abstract：:In order to determine the role of Kir2.2 in the hypercapnic ventilatory response (HCVR) during postnatal development, we measured the response of the Kir2.2-knockout (Kir2.2-/-) mouse in an unanesthetized unrestrained state by means of pressure plethysmography on postnatal days 9-10, 14-15 and 18, and compared the res...

journal_title：Respiratory physiology & neurobiology

authors： Oyamada Y,Yamaguchi K,Murai M,Hakuno H,Ishizaka A

更新日期：2005-02-15 00:00:00

abstract：:Hypoxia inhibits vertebrate development, but the magnitude and timing of organ-specific effects are poorly understood. Chick embryos were exposed continuously to hypoxia (15% O2) throughout Days 1-6, 6-12, 12-18 or Days 1-18 of development, followed by morphometric measurements of major organ systems. Early hypoxic ex...

journal_title：Respiratory physiology & neurobiology

authors： Chan T,Burggren W

更新日期：2005-02-15 00:00:00

abstract：:In order to examine, whether the lobeline-induced cough is a true reflex or a voluntary effort to get rid of its irritating sensations in the upper respiratory tract, we systematically studied the cough response to lobeline, of subjects who were unable to make conscious discriminations i.e. were either comatose (n=4) ...

journal_title：Respiratory physiology & neurobiology

authors： Raj H,Bakshi GS,Tiwari RR,Anand A,Paintal AS

更新日期：2005-01-15 00:00:00